منابع مشابه
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We profiled nucleosome modifications across the yeast genome using chromatin immunoprecipitation coupled with DNA microarrays to produce high-resolution genome-wide maps of histone acetylation and methylation. These maps take into account change...
متن کاملAn epigenetic road map for histone lysine methylation.
Introduction Histone N-termini (tails) undergo diverse post-translational modifications, including acetylation, phosphorylation, methylation, ubiquitination and ADPribosylation (van Holde, 1988; Wolffe, 1998). The discoveries of enzymes that perform these modifications and of chromatin-associated proteins that selectively bind to position-specific histone modifications (Strahl and Allis, 2000; ...
متن کاملDNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease
The central nervous system has a pattern of gene expression that is closely regulated with respect to functional and anatomical regions. DNA methylation is a major regulator of transcriptional activity, and aberrations in the distribution of this epigenetic mark may be involved in many neurological disorders, such as Alzheimer's disease. Herein, we have analysed 12 distinct mouse brain regions ...
متن کاملMethylation Allelic Polymorphism (MAP) in Chorionic Gonadotropin β5 (CGB5) and Its Association with Pregnancy Success
CONTEXT Increased epigenetic variability in the placenta may have evolved in response to its role in mediating the conflicting demands of the mother and fetus. One essential guardian of early pregnancy maintenance is the placental hormone human chorionic gonadotropin (HCG). OBJECTIVE Among the four primate-specific duplicate HCGβ-coding genes, chorionic gonadotropin-β8 (CGB8) and chorionic go...
متن کاملGenome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation
The extent of variation in DNA methylation patterns in healthy individuals is not yet well documented. Identification of inter-individual epigenetic variation is important for understanding phenotypic variation and disease susceptibility. Using neutrophils from a cohort of healthy individuals, we generated base-resolution DNA methylation maps to document inter-individual epigenetic variation. W...
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ژورنال
عنوان ژورنال: Science
سال: 2010
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.327.5971.1305-c